What is Smart Ephys?

Combining the expertise and experience of four companies, we now offer complete solutions for all areas of electrophysiology under the umbrella of “Smart Ephys”.

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Developed by Nobel Prize winners Erwin Neher and Bert Sakmann, this trusted technique is used in electrophysiological studies of ion channels in tissue sections, individual living cells or patches of cell membrane.

Voltage clamp or current clamp technique is performed in any type of excitable cells, mostly neurons, cardiomyocytes, pancreatic beta cells or muscle fibers. Experiments include slice-recordings, single-cell-layer-recordings, in-vivo-recordings, whole-cell-recordings, and single-channel-recordings.

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Electrical activity of electrogenic cells and tissues can be recorded by means of microelectrode arrays (MEAs). These arrays allow simultaneous extracellular recording and stimulation from dozens to thousands of recording sites. Since its introduction more than 40 years ago, the technology has been further developed to include different substrates and electrode materials, as well as Multiwell approaches to increase throughput and CMOS based arrays to increase channel count and spatial resolution.

For a variety of research topics, it is necessary to acquire data from living specimens. Areas including behavior studies, memory functions, or sleep studies require live in vivo data. We offer various platforms for recording and stimulation, tethered or wireless, at low or high channel counts. Depending on your application, experiments may last from minutes to hours or even days; our platforms support all experiment durations.

Ussing chamber systems are critical tools for studying epithelial transport in diverse research areas including genetic disorders, drug discovery and testing, animal nutrition and physiology, the bacterial toxicology.